Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis.

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2023 Jun Others K Preeti, V Fernandes, A Sood, I Khan, DK Khatri… - Metabolic Brain …, 2023 - Springer 78

Full Author : ['Preeti, Kumari', 'Fernandes, Valencia', 'Sood, Anika', 'Khan, Islauddin', 'Khatri, Dharmendra Kumar', 'Singh, Shashi Bala']
Journal Title : Metabolic brain disease
Chapter : Section3
Journal Year : 2023

Type-2 diabetes mellitus (T2DM) is associated with neuroinflammation and cognitive decrement. Necroptosis programmed necrosis is emerging as the major contributing factor to central changes. It is best characterized by the upregulation of p-RIPK(Receptor ..... Read More

Keywords : ["mitigate diabetesassociate cognitive decrement", "lipotoxicityinduced neuromicroglia change", "axis"]
PubMed Link : https://link.springer.com/article/10.1007/s11011-023-01185-8

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Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement and lipotoxicity-induced neuro-microglia changes through p-RIPK-RIPK3-p-MLKL axis.