Involvement of GSK-3beta in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart.
Ischemic preconditioning (IPC) produces cardioprotection by phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) that inhibits the opening of mitochondrial permeability transition pore (MPTP). The activity of glycogen GSK-3beta is elevated during..... Read More