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  • Discovery of biaryl-4-carbonitriles as antihyperglycemic agents that may act through AMPK-p38 MAPK pathway.

Discovery of biaryl-4-carbonitriles as antihyperglycemic agents that may act through AMPK-p38 MAPK pathway.

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2014 Aug 25 Others A Goel, P Nag, N Rahuja, R Srivastava… - Molecular and Cellular …, 2014 - Elsevier

Full Author : ['Goel, Atul', 'Nag, Pankaj', 'Rahuja, Neha', 'Srivastava, Rohit', 'Chaurasia, Sumit', 'Gautam, Sudeep', 'Chandra, Sharat', 'Siddiqi, Mohammad Imran', 'Srivastava, Arvind K']
Journal Title : Molecular and cellular endocrinology
Chapter : Section3
Journal Year : 2014
Cited by : 9.0

A series of functionalized biaryl-4-carbonitriles was synthesized in three steps and evaluated for PTP-1B inhibitory activity. Among the synthesized compounds, four biaryls 6a-d showed inhibition (IC50 58-75 muM) against in vitro PTP-1B assay possibly due..... Read More

Keywords : ["may act", "mapk pathway", "antihyperglycemic agent", "discovery"]
PubMed Link : https://www.sciencedirect.com/science/article/pii/S0303720714001816
Google Scholar Link : https://scholar.google.com/scholar?cites=2845848837772160821&as_sdt=800005&sciodt=0,15&hl=en&num=20