Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT(2) receptor expression in a rat model of type1 diabetes.
BACKGROUND AND PURPOSE: One of the protective actions of angiotensin converting enzyme-2 (ACE2) is the inactivation of angiotensin II. Expression and activity of ACE2 was reduced in glomeruli of diabetic patients and in animal models of diabetes. Recently..... Read More