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  • In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.

In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach.

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2006 Feb Others Fist_Author_Year_PM

Full Author : ['Rao, Gita Subba', 'Ramachandran, Manoj V', 'Bajaj, J S']
Journal Title : Journal of biomolecular structure & dynamics
Chapter : Section3
Journal Year : 2006
Cited by : Not Available

Protein Tyrosine Phosphatase 1B (PTP1B) has been shown to be a negative regulator of insulin signaling by dephosphorylating key tyrosine residues within the regulatory domain of the beta-subunit of the insulin receptor. Recent gene knockout studies in mic.....

Keywords : ["selective small peptide inhibitor", "type diabetes mellitus", "silico structurebase design", "protein tyrosine phosphatase", "novel therapeutic target", "computer model approach", "potent", "obesity"]