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  • Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.

Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.

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2008 Oct 15 Others Fist_Author_Year_PM

Full Author : ['Pingali, Harikishore', 'Jain, Mukul', 'Shah, Shailesh', 'Basu, Sujay', 'Makadia, Pankaj', 'Goswami, Amitgiri', 'Zaware, Pandurang', 'Patil, Pravin', 'Godha, Atul', 'Giri, Suresh', 'Goel, Ashish', 'Patel, Megha', 'Patel, Harilal', 'Patel, Pankaj']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2008
Cited by : Not Available

A series of novel 1,3-dioxane-2-carboxylic acid derivatives containing alkyl chain tether and substituted phenyl group as a lipophilic tail have been prepared as agonists of PPARalpha and gamma. c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxa.....

Keywords : ["highly orally bioavailable acid", "potent hypoglycemic", "hypolipidemic agent", "discovery"]