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  • Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.

Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.

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2010 Oct 1 Others Fist_Author_Year_PM

Full Author : ['Gupta, Swati', 'Pandey, Gyanendra', 'Rahuja, Neha', 'Srivastava, Arvind K', 'Saxena, Anil K']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2010
Cited by : Not Available

A series of substituted phenoxy-3-piperazin-1-yl-propan-2-ols has been synthesized and evaluated for PTP1B inhibitory activity in vitro and for antidiabetic activity in vivo. Two molecules viz. 4a and 5b showed PTP1B inhibition of 31.58% and 35.90% at 100.....

Keywords : ["protein tyrosine phosphatase inhibitor", "dock study", "design synthesis", "derivative"]