Risk of obesity and type 2 diabetes with tumor necrosis factor-alpha 308G/A gene polymorphism in metabolic syndrome and coronary artery disease subjects.
Tumor Necrosis Factor-alpha (TNF-alpha) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-alpha in adipose tissue is known to induce insulin resistance, and a polymorphism at position -308 in the pr.....