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  • Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

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2016 Jul Others Fist_Author_Year_PM

Full Author : ['Vedovato, Natascia', 'Cliff, Edward', 'Proks, Peter', 'Poovazhagi, Varadarajan', 'Flanagan, Sarah E', 'Ellard, Sian', 'Hattersley, Andrew T', 'Ashcroft, Frances M']
Journal Title : Diabetologia
Chapter : Section3
Journal Year : 2016
Cited by : Not Available

AIMS/HYPOTHESIS: The pancreatic ATP-sensitive potassium (KATP) channel plays a pivotal role in linking beta cell metabolism to insulin secretion. Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mel.....

Keywords : ["atp sensitivity markedly affect diabetes risk", "neonatal diabete cause", "homozygous mutation demonstrate", "tiny change"]