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  • The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).

The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).

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2016 Dec 22 Others Fist_Author_Year_PM

Full Author : ['Hamdouchi, Chafiq', 'Kahl, Steven D', 'Patel Lewis, Anjana', 'Cardona, Guemalli R', 'Zink, Richard W', 'Chen, Keyue', 'Eessalu, Thomas E', 'Ficorilli, James V', 'Marcelo, Marialuisa C', 'Otto, Keith A', 'Wilbur, Kelly L', 'Lineswala, Jayana P', 'Piper, Jared L', 'Coffey, D Scott', 'Sweetana, Stephanie A', 'Haas, Joseph V', 'Brooks, Dawn A', 'Pratt, Edward J', 'Belin, Ruth M', 'Deeg, Mark A', 'Ma, Xiaosu', 'Cannady, Ellen A', 'Johnson, Jason T', 'Yumibe, Nathan P', 'Chen, Qi', 'Maiti, Pranab', 'Montrose-Rafizadeh, Chahrzad', 'Chen, Yanyun', 'Reifel Miller, Anne']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2016
Cited by : Not Available

The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence of .....

Keywords : ["type diabetes mellitus", "early clinical development", "selective agonist", "discovery preclinical", "treatment", "potent"]