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  • Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach.

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach.

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2017 Others Fist_Author_Year_PM

Full Author : ['P, Sneha', 'D, Thirumal Kumar', 'C, George Priya Doss', 'R, Siva', 'Zayed, Hatem']
Journal Title : PloS one
Chapter : Section3
Journal Year : 2017
Cited by : Not Available

Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the Hepatocyte Nuclear Factor 1 Alpha.....

Keywords : ["pou domain", "missense mutation", "dnabinding affinity", "computational approach", "role", "reduce", "determine"]