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  • Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.

Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.

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2018 Feb 8 Others Fist_Author_Year_PM

Full Author : ['Hamdouchi, Chafiq', 'Maiti, Pranab', 'Warshawsky, Alan M', 'DeBaillie, Amy C', 'Otto, Keith A', 'Wilbur, Kelly L', 'Kahl, Steven D', 'Patel Lewis, Anjana', 'Cardona, Guemalli R', 'Zink, Richard W', 'Chen, Keyue', 'Cr, Siddaramaiah', 'Lineswala, Jayana P', 'Neathery, Grace L', 'Bouaichi, Cecilia', 'Diseroad, Benjamin A', 'Campbell, Alison N', 'Sweetana, Stephanie A', 'Adams, Lisa A', 'Cabrera, Over', 'Ma, Xiaosu', 'Yumibe, Nathan P', 'Montrose-Rafizadeh, Chahrzad', 'Chen, Yanyun', 'Miller, Anne Reifel']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2018
Cited by : Not Available

As a part of our program to identify potent GPR40 agonists capable of being dosed orally once daily in humans, we incorporated fused heterocycles into our recently disclosed spiropiperidine and tetrahydroquinoline acid derivatives 1, 2, and 3 with the int.....

Keywords : ["selective g proteincouple receptor agonist", "type diabetes mellitus", "optimize pharmacokinetic property", "daily oral treatment", "support", "potent", "patient", "discovery"]