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  • Eplerenone pretreatment protects the myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

Eplerenone pretreatment protects the myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats.

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2018 Sep Others Fist_Author_Year_PM

Full Author : ['Mahajan, Umesh B', 'Patil, Pradip D', 'Chandrayan, Govind', 'Patil, Chandragouda R', 'Agrawal, Yogeeta O', 'Ojha, Shreesh', 'Goyal, Sameer N']
Journal Title : Molecular and cellular biochemistry
Chapter : Section3
Journal Year : 2018
Cited by : Not Available

We investigated the eplerenone-induced, PI3K/Akt- and GSK-3beta-mediated cardioprotection against ischemia/reperfusion (I/R) injury in diabetic rats. The study groups comprising diabetic rats were treated for 14 days with 150 mg/kg/day eplerenone orally a.....

Keywords : ["eplerenone pretreatment protect", "phosphatidylinositol pathway", "ischaemiareperfusion injury", "diabetic rat", "myocardium"]