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  • Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.

Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.

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2018 Jun 1 Others Fist_Author_Year_PM

Full Author : ['Agarwal, Sameer', 'Sasane, Santosh', 'Kumar, Jeevan', 'Deshmukh, Prashant', 'Bhayani, Hitesh', 'Giri, Poonam', 'Giri, Suresh', 'Soman, Shubhangi', 'Kulkarni, Neelima', 'Jain, Mukul']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2018
Cited by : Not Available

TGR5 is a member of G protein-coupled receptor (GPCR) superfamily, a promising molecular target for metabolic diseases. Activation of TGR5 promotes secretion of glucagon-like peptide-1 (GLP-1), which activates insulin secretion. A series of 2-thio-imidazo.....

Keywords : ["type diabetes", "possible treatment", "novel agonist", "sitagliptin", "evaluation", "combination"]