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  • Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches.

Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches.

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2018 Others Fist_Author_Year_PM

Full Author : ['Shinde, Ranajit Nivrutti', 'Kumar, G Siva', 'Eqbal, Shahbaz', 'Sobhia, M Elizabeth']
Journal Title : PloS one
Chapter : Section3
Journal Year : 2018
Cited by : Not Available

Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for Type 2 diabetes due to its specific role as a negative regulator of insulin signaling pathways. Discovery of active site directed PTP1B inhibitors is very challenging due to hig.....

Keywords : ["potential allosteric inhibitor use", "vitro approach", "silico", "screening", "identification"]