Naringin (4',5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates beta-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1.
BACKGROUND: Pancreatic duodenal homeobox-1 (PDX-1) is a key transcription factor which regulates Insulin gene expression and insulin secretion in adult beta-cells and helps to maintain beta-cells mass. Naringin, a flavanone, owing to its anti-oxidant prop.....