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  • Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation.

Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation.

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2020 Dec Others Fist_Author_Year_PM

Full Author : ['Kalvala, Anil Kumar', 'Yerra, Veera Ganesh', 'Sherkhane, Bhoomika', 'Gundu, Chayanika', 'Arruri, Vijay', 'Kumar, Rahul', 'Kumar, Ashutosh']
Journal Title : Pharmacological reports : PR
Chapter : Section3
Journal Year : 2020
Cited by : Not Available

BACKGROUND: Disturbed mitochondrial homeostasis has been identified to contribute to the pathogenesis of diabetic neuropathy (DN). However, the role of Mitochondrial Lon peptidase 1 (Lonp1) and Heat shock proteins (HSP's) in DN remains elusive. Here we st.....

Keywords : ["chronic hyperglycemia impair mitochondrial unfold protein response", "experimental diabetic neuropathy focus", "mediate mitochondrial regulation", "precipitate proteotoxicity"]