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  • Blocking TLR4-NF-kappaB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion.

Blocking TLR4-NF-kappaB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion.

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2021 Jul 15 Others Fist_Author_Year_PM

Full Author : ['Mukhuty, Alpana', 'Fouzder, Chandrani', 'Kundu, Rakesh']
Journal Title : Molecular and cellular endocrinology
Chapter : Section3
Journal Year : 2021
Cited by : Not Available

Lipid mediated pancreatic beta-cell dysfunction during Type 2 diabetes is known to be regulated by activation of TLR4 (Toll Like Receptor 4) and NF-kappaB (Nuclear factor kappa B). Recently we have reported that MIN6 cells (mouse insulinoma cells) secrete.....

Keywords : ["block pathway protect mouse islet", "fetuina mediate dysfunction", "restore ability", "insulin secretion", "high fat", "combinatorial impact"]