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  • Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.

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2022 Jul 6 Others Fist_Author_Year_PM

Full Author : ['Maity, Debabrata', 'Oh, Yujeong', 'Gremer, Lothar', 'Hoyer, Wolfgang', 'Magzoub, Mazin', 'Hamilton, Andrew D']
Journal Title : Chemistry (Weinheim an der Bergstrasse, Germany)
Chapter : Section3
Journal Year : 2022
Cited by : Not Available

Two "hot segments" within an islet amyloid polypeptide are responsible for its self-assembly, which in turn is linked to the decline of beta-cells in type 2 diabetes (T2D). A readily available water-soluble, macrocyclic host, cucurbit[7]uril (CB[7]), effe.....

Keywords : ["cucurbituril inhibit islet amyloid polypeptide aggregation", "target n terminus hot segment", "attenuate cytotoxicity"]