Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity.

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2023 Apr Others Fist_Author_Year_PM 58

Full Author : ['Babkov, Denis A', 'Zhukovskaya, Olga N', 'Brigadirova, Anastasia A', 'Prilepskaya, Diana R', 'Kolodina, Alexandra A', 'Abbas, Abbas Haider S', 'Morkovnik, Anatolii S', 'Sobhia, M Elizabeth', 'Ghosh, Ketan', 'Spasov, Alexander A']
Journal Title : Chemical biology & drug design
Chapter : Section3
Journal Year : 2023
Cited by : Not Available

This work describes the synthesis of series hydrobromides of N-(4-biphenyl)methyl-N'-dialkylaminoethyl-2-iminobenzimidazoles, which, due to the presence of two privileged structural fragments (benzimidazole and biphenyl moieties), can be considered as bi-.....

Keywords : ["vivo antidiabetic activity", "prototype dual inhibitor", "biphenyl derivative", "ampk activator", "evaluation", "discovery"]

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Discovery and evaluation of biphenyl derivatives of 2-iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity.