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  • A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.

A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.

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2023 Mar 9 Others Fist_Author_Year_PM

Full Author : ['Laghezza, Antonio', 'Cerchia, Carmen', 'Genovese, Massimo', 'Leuci, Rosalba', 'Pranzini, Erica', 'Santi, Alice', 'Brunetti, Leonardo', 'Piemontese, Luca', 'Tortorella, Paolo', 'Biswas, Abanish', 'Singh, Ravi Pratap', 'Tambe, Suhas', 'Ca, Sudeep', 'Pattnaik, Ashok Kumar', 'Jayaprakash, Venkatesan', 'Paoli, Paolo', 'Lavecchia, Antonio', 'Loiodice, Fulvio']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2023
Cited by : Not Available

A new series of analogues or derivatives of the previously reported PPARalpha/gamma dual agonist LT175 allowed the identification of ligand 10, which was able to potently activate both PPARalpha and -gamma subtypes as full and partial agonists, respective.....

Keywords : ["peroxisome proliferatoractivated receptor alphagamma dual agonism", "new antidiabetic agent show short", "mitochondrial pyruvate carrier inhibition", "longterm effect due"]