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  • Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial.

Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial.

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2023 May RCTs Fist_Author_Year_PM

Full Author : ["O'Rourke, Matthew B", 'Januszewski, Andrzej S', 'Sullivan, David R', 'Lengyel, Imre', 'Stewart, Alan J', 'Arya, Swati', 'Ma, Ronald C', 'Galande, Sanjeev', 'Hardikar, Anandwardhan A', 'Joglekar, Mugdha V', 'Keech, Anthony C', 'Jenkins, Alicia J', 'Molloy, Mark P']
Journal Title : Proteomics. Clinical applications
Chapter : Section3
Journal Year : 2023
Cited by : Not Available

PURPOSE: Robust, affordable plasma proteomic biomarker workflows are needed for large-scale clinical studies. We evaluated aspects of sample preparation to allow liquid chromatography-mass spectrometry (LC-MS) analysis of more than 1500 samples from the F.....

Keywords : ["optimise plasma sample preparation", "clinical trial specimen application", "support largescale proteomic analysis", "diabetes field trial", "lcms analysis", "fenofibrate intervention", "event lower"]