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  • Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibitors.

Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibitors.

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2023 Mar 23 Others Fist_Author_Year_PM

Full Author : ['Hartz, Richard A', 'Ahuja, Vijay T', 'Sivaprakasam, Prasanna', 'Xiao, Hong', 'Krause, Carol M', 'Clarke, Wendy J', 'Kish, Kevin', 'Lewis, Hal', 'Szapiel, Nicolas', 'Ravirala, Ramu', 'Mutalik, Sayali', 'Nakmode, Deepa', 'Shah, Devang', 'Burton, Catherine R', 'Macor, John E', 'Dubowchik, Gene M']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2023
Cited by : Not Available

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates numerous cellular processes, including metabolism, proliferation, and cell survival. Due to its multifaceted role, GSK-3 has been implicated in a variety of diseases, including.....

Keywords : ["glycogen synthase inhibitor", "design structureactivity relationship", "vivo evaluation", "brainpenetrant imidazopyridazine", "potent"]