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  • Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.

Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.

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2023 Jun 8 Others Fist_Author_Year_PM

Full Author : ['Hartz, Richard A', 'Ahuja, Vijay T', 'Luo, Guanglin', 'Chen, Ling', 'Sivaprakasam, Prasanna', 'Xiao, Hong', 'Krause, Carol M', 'Clarke, Wendy J', 'Xu, Songmei', 'Tokarski, John S', 'Kish, Kevin', 'Lewis, Hal', 'Szapiel, Nicolas', 'Ravirala, Ramu', 'Mutalik, Sayali', 'Nakmode, Deepa', 'Shah, Devang', 'Burton, Catherine R', 'Macor, John E', 'Dubowchik, Gene M']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2023
Cited by : Not Available

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that serves as an important regulator of a broad range of cellular functions. It has been linked to Alzheimer's disease as well as various other diseases, including mood disorders, type 2 dia.....

Keywords : ["orally active glycogen synthase inhibitor", "highly potent selective", "discovery"]