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  • (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.

(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.

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2001 Aug 2 Others Fist_Author_Year_PM

Full Author : ['Lohray, B B', 'Lohray, V B', 'Bajji, A C', 'Kalchar, S', 'Poondra, R R', 'Padakanti, S', 'Chakrabarti, R', 'Vikramadithyan, R K', 'Misra, P', 'Juluri, S', 'Mamidi, N V', 'Rajagopalan, R']
Journal Title : Journal of medicinal chemistry
Chapter : Section3
Journal Year : 2001
Cited by : Not Available

(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compare.....

Keywords : ["lipid modulate activity", "dual ppar agonist", "potent antihyperglycemic", "acid"]