Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus.
BACKGROUND: Repaglinide (RPG) is an oral hypoglycemic agent with excellent bioavailability (90-98%) and a short plasma half-life (2-6 h). A full dose of RPG is required before each meal; hence, therapy may become inconvenient. Thus, the aim of the present.....