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  • A novel long acting DPP-IV inhibitor PKF-275-055 stimulates beta-cell proliferation resulting in improved glucose homeostasis in diabetic rats.

A novel long acting DPP-IV inhibitor PKF-275-055 stimulates beta-cell proliferation resulting in improved glucose homeostasis in diabetic rats.

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2012 Jan 15 Others Fist_Author_Year_PM

Full Author : ['Akarte, Atul Sureshrao', 'Srinivasan, B P', 'Gandhi, Sonia']
Journal Title : Biochemical pharmacology
Chapter : Section3
Journal Year : 2012
Cited by : Not Available

The enzyme dipeptidyl peptidase-IV (DPP-4) inactivates the incretin hormone glucagon-like peptide-1 (GLP-1). GLP-1 has therapeutic effects in patients with type 2 diabetes, but its potential is limited by a short half-life, DPP-4 inhibition is a promising.....

Keywords : ["novel long act dppiv inhibitor stimulate betacell proliferation result", "improved glucose homeostasis", "diabetic rat"]