Identification of important chemical features of 11beta-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theory.
11beta-Hydroxysteroid dehydrogenase type1 (11betaHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11betaHSD1 has been thought of as an effective approach for .....