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  • Vildagliptin selectively ameliorates GLP-1, GLUT4, SREBP-1c mRNA levels and stimulates beta-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes.

Vildagliptin selectively ameliorates GLP-1, GLUT4, SREBP-1c mRNA levels and stimulates beta-cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes.

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2012 Jul-Aug Others Fist_Author_Year_PM

Full Author : ['Akarte, Atul Sureshrao', 'Srinivasan, B P', 'Gandhi, Sonia']
Journal Title : Journal of diabetes and its complications
Chapter : Section3
Journal Year : 2012
Cited by : Not Available

OBJECTIVE: Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of incretin hormones, exert antihyperglycemic effects in type 2 diabetic patients. A major unanswered question concerns the potential ability of DPP-4 inhibition to ha.....

Keywords : ["vildagliptin selectively ameliorate mrna level", "stimulate betacell proliferation result", "improved glucose homeostasis", "streptozotocininduce diabetes", "rat"]