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  • Synthesis, characterization, biological evaluation and docking of coumarin coupled thiazolidinedione derivatives and its bioisosteres as PPARgamma agonists.

Synthesis, characterization, biological evaluation and docking of coumarin coupled thiazolidinedione derivatives and its bioisosteres as PPARgamma agonists.

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2012 Sep Others Fist_Author_Year_PM

Full Author : ['Shukla, Shubhanjali', 'Kumar, Pankaj', 'Das, Nirupam', 'Moorthy, N S Hari Narayana', 'Shrivastava, Sushant Kumar', 'Trivedi, Piyush', 'Srivastava, Radhey Shyam']
Journal Title : Medicinal chemistry (Shariqah (United Arab Emirates))
Chapter : Section3
Journal Year : 2012
Cited by : Not Available

Thiazolidinedione (TZD) derivatives are the novel class of oral antidiabetic drugs which are selective agonist for the nuclear PPAR gamma that enhances the transcription of several insulin responsive genes but TZDs are known to cause weight gain, hepatoto.....

Keywords : ["synthesis characterization biological evaluation", "coumarin couple thiazolidinedione derivative", "ppargamma agonist", "docking", "bioisostere"]