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  • Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents.

Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents.

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2012 Sep 15 Others Fist_Author_Year_PM

Full Author : ['Shah, Kiran', 'Patel, Dipam', 'Jadav, Pradip', 'Sheikh, Mubeen', 'Sairam, Kalapatapu V V M', 'Joharapurkar, Amit', 'Jain, Mukul R', 'Bahekar, Rajesh']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2012
Cited by : Not Available

Series of benzyl-phenoxybenzyl amino-phenyl acid derivatives (8a-q) are reported as non-steroidal GR antagonist. Compound 8g showed excellent h-GR binding and potent antagonistic activity (in vitro). The lead compound 8g exhibited significant oral antidia.....

Keywords : ["liver selective nonsteroidal glucocorticoid receptor antagonist", "novel antidiabetic agent", "discovery"]