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Development of pectinate-ispagula mucilage mucoadhesive beads of metformin HCl by central composite design.

Ionotropically-gelled mucoadhesive beads of metformin HCl composed of low methoxy (LM) pectin-ispaghula husk mucilage (IHM) polymer-blend was developed and optimized using central composite design (spherical type, single center point, and alpha=1.414). Ef.....