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  • CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.

CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.

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2014 Mar 25 Others Fist_Author_Year_PM

Full Author : ['Sunil, Venkategowda', 'Verma, Mahesh Kumar', 'Oommen, Anup M', 'Sadasivuni, Manojkumar', 'Singh, Jaideep', 'Vijayraghav, Dasarahalli N', 'Chandravanshi, Bhawna', 'Shetty, Jayalaxmi', 'Biswas, Sanghamitra', 'Dandu, Anilkumar', 'Moolemath, Yoganand', 'Venkataranganna, Marikunte V', 'Somesh, Baggavalli P', 'Jagannath, Madanahalli R']
Journal Title : BMC pharmacology & toxicology
Chapter : Section3
Journal Year : 2014
Cited by : Not Available

BACKGROUND: GPR40 is a G-protein coupled receptor regulating free fatty acid induced and also glucose induced insulin secretion. We generated neonatally-streptozotocin-treated female rats (n-STZ) and treated them with CNX-011-67, a GPR40 agonist to examin.....

Keywords : ["novel agonist enhance glucose responsiveness insulin secretion", "islet insulin content", "type diabetic patient", "nstz rat", "islet"]