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  • Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients.

Mutations in exons 10 and 11 of human glucokinase result in conformational variations in the active site of the structure contributing to poor substrate binding - explains hyperglycemia in type 2 diabetic patients.

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2015 Others Fist_Author_Year_PM

Full Author : ['Yellapu, Nandakumar', 'Mahto, Manoj Kumar', 'Valasani, Koteswara Rao', 'Sarma, P V G K', 'Matcha, Bhaskar']
Journal Title : Journal of biomolecular structure & dynamics
Chapter : Section3
Journal Year : 2015
Cited by : Not Available

Mutations in the glucokinase (GK) gene play a critical role in the establishment of type 2 diabetes. In our earlier study, R308K mutation in GK in a clinically proven type 2 diabetic patient showed, structural and functional variations that contributed im.....

Keywords : ["poor substrate bind explain hyperglycemia", "type diabetic patient", "human glucokinase result", "structure contribute", "conformational variation", "active site", "mutation", "exon"]