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  • Thiazolidine-2,4-diones derivatives as PPAR-gamma agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-gamma gene expression.

Thiazolidine-2,4-diones derivatives as PPAR-gamma agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-gamma gene expression.

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2014 Jul 15 Others Fist_Author_Year_PM

Full Author : ['Nazreen, Syed', 'Alam, Mohammad Sarwar', 'Hamid, Hinna', 'Yar, Mohammad Shahar', 'Dhulap, Abhijeet', 'Alam, Perwez', 'Pasha, M A Q', 'Bano, Sameena', 'Alam, Mohammad Mahboob', 'Haider, Saqlain', 'Kharbanda, Chetna', 'Ali, Yakub', 'Pillai, K K']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2014
Cited by : Not Available

A library of conjugates of chromones and 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C as a catalyst. Compounds 5c and 5e were most effective in lowering the blood glucose level co.....

Keywords : ["ppargamma agonist synthesis molecular docking", "ppargamma gene expression", "vivo antidiabetic activity", "hepatotoxicity risk evaluation", "vitro", "effect", "derivative"]