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  • Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.

Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.

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2014 Aug Others Fist_Author_Year_PM

Full Author : ['Kumar, Premranjan', 'Rao, G Nageswar', 'Pal, Bibhuti Bhusan', 'Pal, Arttatrana']
Journal Title : The international journal of biochemistry & cell biology
Chapter : Section3
Journal Year : 2014
Cited by : Not Available

Glial cells are very important for normal brain function and alterations in their activity due to hyperglycemia, could contribute to diabetes-related cognitive dysfunction. Oxidative insults often cause rapid changes in almost all cells including glial ce.....

Keywords : ["mapk mediate signal pathway cause downregulation", "hyperglycemiainduce oxidative stress induce apoptosis", "glycosylase level", "glial cell", "inhibit"]