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  • Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.

Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.

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2015 Apr Others Fist_Author_Year_PM

Full Author : ['Kushwaha, Ram N', 'Srivastava, Rohit', 'Mishra, Akansha', 'Rawat, Arun K', 'Srivastava, Arvind K', 'Haq, Wahajul', 'Katti, Seturam B']
Journal Title : Chemical biology & drug design
Chapter : Section3
Journal Year : 2015
Cited by : Not Available

Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, 1-(2-(4-(7-Chloro-4-quinolyl)piperazin-.....

Keywords : ["design synthesis biological screening", "piperazinederive constrain inhibitor", "molecular docking study", "type diabetes", "treatment", "dppiv"]