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  • Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes.

Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes.

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2015 Oct 15 Others Fist_Author_Year_PM

Full Author : ['Sagar, Sneha R', 'Agarwal, Jessica K', 'Pandya, Dhaivat H', 'Dash, Ranjeet Prasad', 'Nivsarkar, Manish', 'Vasu, Kamala K']
Journal Title : Bioorganic & medicinal chemistry letters
Chapter : Section3
Journal Year : 2015
Cited by : Not Available

We report the design, synthesis, biological activity and docking studies of series of novel pyrazolo[3,4-d]pyrimidinones as DPP-IV inhibitors in diabetes. Molecules were synthesized and evaluated for their DPP-IV inhibition activity. Compounds 5e, 5k, 5o .....

Keywords : ["novel pyrazolopyrimidinone", "dppiv inhibitor", "design synthesis", "biological evaluation", "diabetes"]