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  • Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3beta and mitochondrial permeability transition pore.

Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3beta and mitochondrial permeability transition pore.

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2016 Feb Others Fist_Author_Year_PM

Full Author : ['Rana, Ajay', 'Sharma, Saurabh']
Journal Title : Clinical and experimental pharmacology & physiology
Chapter : Section3
Journal Year : 2016
Cited by : Not Available

There is growing evidence that diabetes mellitus causes attenuation of the bioactive metabolite of membrane sphingolipids, sphingosine-1-phosphate, and this may be a key mechanism in the decreased cardioprotective effect of ischaemic preconditioning (IPC).....

Keywords : ["diabetic rat heart possible involvement", "mitochondrial permeability transition pore", "glycogen synthase kinase", "ir injury", "induce cardioprotection", "mechanism"]