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  • The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.

The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and differentially affects cleavage of ANGPTL3.

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2016 Jun Others Fist_Author_Year_PM

Full Author : ['Hanson, Robert L', 'Leti, Fatjon', 'Tsinajinnie, Darwin', 'Kobes, Sayuko', 'Puppala, Sobha', 'Curran, Joanne E', 'Almasy, Laura', 'Lehman, Donna M', 'Blangero, John', 'Duggirala, Ravindranath', 'DiStefano, Johanna K']
Journal Title : Molecular genetics and metabolism
Chapter : Section3
Journal Year : 2016
Cited by : Not Available

We previously identified a locus linked to total cholesterol (TC) concentration in Pima Indians on chromosome 19p. To characterize this locus, we genotyped >2000 SNPs in 1838 Pimas and assessed association with log(TC). We observed evidence for associatio.....

Keywords : ["differentially affect cleavage", "mexican americans", "american indians", "variant", "total", "hdlcholesterol", "betatrophin", "associate"]