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  • Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors.

Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors.

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2016 Nov 29 Others Fist_Author_Year_PM

Full Author : ['Gopinath, Gudipudi', 'Sankeshi, Venu', 'Perugu, Shaym', 'Alaparthi, Malini D', 'Bandaru, Srinivas', 'Pasala, Vijay K', 'Chittineni, Prasad Rao', 'Krupadanam, G L David', 'Sagurthi, Someswar R']
Journal Title : European journal of medicinal chemistry
Chapter : Section3
Journal Year : 2016
Cited by : Not Available

Aldose reductase (ALR2) inhibitors provide a viable mode to fight against diabetic complications. ALR2 exhibit plasticity in the active site vicinities and possible shifts in the nearby two supporting alpha helices. Therefore, a novel series of amino acid.....

Keywords : ["chiral acid conjugate", "aldose reductase inhibitor", "synthesis", "design"]